Tetrahedron Letters p. 583 - 586 (2003)
Update date:2022-08-03
Topics:
Mathew, Jessy
Farber, Ken
Nakanishi, Hiroshi
Qabar, Maher
Asymmetric synthesis of the two enantiomers of a small molecule thrombin inhibitor is described. The key step in the synthesis is the glucose-directed chiral induction in the hetero Diels-Alder cycloaddition step. Conformational analysis indicates that th
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