A New Two-Step Preparation of Pyrroles from β-Amino Ketones Utilizing Trimethylsilyldiazomethane

Article abstract of DOI:10.1055/s-1997-1552

Lithium trimethylsilyldiazomethane smoothly reacted with N-substituted β-amino ketones to give 2-pyrrolines which were easily converted to the corresponding pyrroles by treatment with MnO₂ (CMD, chemical manganese dioxide). The reaction with N,N-disubstituted β-amino ketones followed by oxidation with CMD also afforded pyrroles.