Journal of Medicinal Chemistry p. 1831 - 1844 (2003)
Update date:2022-08-04
Topics:
Smith III, Amos B.
Cantin, Louis-David
Pasternak, Alexander
Guise-Zawacki, Lisa
Yao, Wenquin
Charnley, Adam K.
Barbosa, Joseph
Sprengeler, Paul A.
Hirschmann, Ralph
Munshi, Sanjeev
Olsen, David B.
Schleif, William A.
Kuo, Lawrence C.
The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors with i
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(2004)
