10.1002/anie.202010845
Angewandte Chemie International Edition
COMMUNICATION
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Figure 2. Plausible mechanism.
In conclusion, we have developed a protocol for palladium-
catalyzed synthesis of ortho-alkyl-substituted phenols from
phenols and primary alcohols via
rearomatization strategy. Water was the sole by-product of the
reaction, making it sustainable method for site-specific
a
dearomatization–
a
synthesis of these phenols.
Acknowledgements
We thank Prof. Lu Li (Jilin University) for his helpful discussions.
We thank the NSFC (21971093), the International Joint Research
Centre for Green Catalysis and Synthesis (grant nos.
2016B01017, 18JR3RA284, and 18JR4RA003), and the 111
project for support of our research. We also thank the Canada
Research Chair (Tier I) foundation, the E.B. Eddy Endowment
Fund, the CFI, NSERC, and FQRNT to C.-J. Li.
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Keywords: dearomatization–rearomatization • ortho-substituted
phenol • primary alcohol • palladium-catalysis
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