Tetrahedron Asymmetry p. 1683 - 1688 (1994)
Update date:2022-08-03
Topics:
Srivastava, Ranjan P.
Zjawiony, Jordan K.
Peterson, John R.
McChesney, James D.
The importance of N-benzoyl (2R,3S)-phenylisoserine (3), also known as the "taxol side chain", for the strong antitumor activity of taxol (1), a potent anticancer drug, has prompted numerous efforts towards the development of a practical taxol side chain synthesis.Here we describe a highly practical and inexpensive synthesis of the taxol side chain methyl ester 4 and resolution via entrainment based on the observation that compound 4 exhibits conglomerate crystal structure.
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