Monofluorination of fluorinated ethers with high-valency metal fluorides

Article abstract of DOI:10.1016/S0022-1139(97)00075-4

Fluorinated ethers were fluorinated by high-valency metal fluorides such as MnF₃, CoF₃, and KCoF₄. The monofluorinating reactivities of these reagents with 2,2,2-trifluoroethyl difluoromethyl ether, bis(2,2,2-trifluoroethyl) ether, and 2-chloro-1, 1,2-trifluoroethyl methyl ether follow the order MnF₃ > CoF₃ > KCoF₄. The order of monofluorination reactivity with fluorinated ethers did not agree with that of gemdifluorohydrofluorocarbons (CoF₃ > MnF₃ > KCoF₄). Regioselective monofluorination of 2,2,2-trifluoroethoxy compounds with MnF₃ was achieved at the methylene position adjacent to the trifluoromethyl group.