Synthesis of pyridine-fused ring systems from β-chloroacroleins: A comparison of three different pathways

Article abstract of DOI:10.1055/s-2003-38081

Three different pathways for the access of pyridine-fused ring systems are described: 1) a Sonogashira coupling of β-chloroacroleins followed by cyclization of the corresponding imines; 2) the same coupling reaction followed by cyclization of the corresponding oximes; and 3) a palladium-catalyzed iminoannulation of internal alkynes.