Bicyclomycin fluorescent probes: Synthesis and biochemical, biophysical, and biological properties

Article abstract of DOI:10.1021/jo030020u

Bicyclomycin (1) is a commercially available antibiotic whose primary site of action in Escherichia coli is the transcription termination factor rho. Key aspects of the 1·rho interaction - K_d, stoichiometry for 1·rho binding, and whether 1 and