Journal of Medicinal Chemistry p. 1483 - 1487 (1979)
Update date:2022-07-29
Topics:
Miller
Mylari
Howes Jr.
Lynch
Lynch
Koch
Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were related in part to the acidity of the imide hydrogen. Maximum effects were shown by phenyl rings substituted in both meta positions by compact, electron-withdrawing, lipophilic substituents, as in 1-(3',5'-dichlorophenyl)-6 azauracil, which had a plasma half-life of 160 h and a potency 250-fold greater than that of 6-azauracil.
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Doi:10.3109/00498259409043246
(1994)Doi:10.1021/jo00871a044
(1976)Doi:10.1002/hlca.19750580841
(1975)Doi:10.1039/j39660000955
(1966)Doi:10.1016/S0008-6215(00)90430-0
(1986)Doi:10.1016/0040-4020(75)80266-3
(1975)
