An Approach to Enhance Specificity against RNA Targets Using Heteroconjugates of Aminoglycosides and Chloramphenicol (or Linezolid)

DOI: 10.1021/ja038937y

Source and publish data:

Journal of the American Chemical Society p. 1956 - 1957 (2004)

Update date:2022-08-03

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Authors:

Lee, Jongkook

Kwon, Miyun

Lee, Kyung Hyun

Jeong, Sunjoo

Hyun, Soonsil

Shin, Kye Jung

Yu, Jaehoon

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Article abstract of DOI:10.1021/ja038937y

We describe the design and synthesis of new heterodimeric conjugates, which are comprised of a neomycin B (Neo) stem-binding component and a chloramphenicol (Cam) or linezolid (Lnz) loop-binding component. Some of the heterodimeric conjugates display enha

Full text of DOI:10.1021/ja038937y

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