Total synthesis of nonactin

Article abstract of DOI:10.1016/0040-4020(95)00913-2

Utilizing the efficient preparation of (+)-nonactic acid (2a) and (-)-methyl-8-epi-nonactate (4b) starting from optically active 2-isoxazolines 5a and 5b, respectively, the total synthesis of nonactin has been accomplished. Based on the high dilution version of the Yamaguchi's method, the final macrolactonization has been completed in high yield.