Conversion of biguanides into substituted s triazines assayable by GC or mass fragmentography

Article abstract of DOI:10.1002/jps.2600650412

Substituted s triazines were prepared by the treatment of biguanides with various organic acid anhydrides. This reaction permits the ready conversion of the hypoglycemic drugs, phenformin, buformin, and metformin and of other analogous biguanides into compounds suitable for GC and mass fragmentographic determination with a high degree of sensitivity. Mass spectral data and Kovats retention indexes are presented for all s triazines prepared for this study.