A Comparative Investigation: Group 9 Cp?M(III)-Catalyzed Formal [4 + 2] Cycloaddition as an Atom-Economic Approach to Quinazolines

DOI: 10.1021/acs.orglett.6b00716

Source and publish data:

Organic Letters p. 2090 - 2093 (2016)

Update date:2022-08-04

Topics:

Authors:

Wang, Xiaoming

Lerchen, Andreas

Glorius, Frank

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Article abstract of DOI:10.1021/acs.orglett.6b00716

A comparative study on the catalytic activity of different group 9 [Cp?M(III)] complexes in the formal [4 + 2] cycloaddition of arenes with rarely explored free imines and dioxazolones for the construction of multisubstituted quinazolines is reported herein. This investigation revealed that the cobalt catalyst is uniquely suited to this transformation due to its strong Lewis acidity and high sensitivity to steric hindrance.

Full text of DOI:10.1021/acs.orglett.6b00716

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