Asymmetric synthesis of the highly potent anti-metastatic prostacyclin analogue cicaprost and its isomer isocicaprost

DOI: 10.1021/ja030200l

Source and publish data:

Journal of the American Chemical Society p. 9653 - 9667 (2003)

Update date:2022-08-04

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Authors:

Lerm, Marco

Gais, Hans-Joachim

Cheng, Kejun

Vermeeren, Cornelia

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Article abstract of DOI:10.1021/ja030200l

An asymmetric synthesis of the anti-metastatic prostacyclin analogue cicaprost and a formal one of its isomer isocicaprost by a new route are described. A key step of these syntheses is the coupling of a chiral bicyclic C6-C14 ethynyl building block with

Full text of DOI:10.1021/ja030200l

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