Bioorganic and Medicinal Chemistry Letters p. 3276 - 3280 (2018)
Update date:2022-08-05
Topics: Synthesis Column chromatography Melting point Yield NMR spectroscopy Derivatives Recrystallization Mass spectrometry (MS) IC50 Solubility Pharmacophore Cytotoxicity Enzyme inhibition Docking Studies Structure-Activity Relationship (SAR) Anti-Inflammatory Activity Bioactivity In vitro assay In vivo assay Heterocyclic compound PDE4 inhibitors Lipinski’s Rule of Five
Hu, De-Kun
Zhao, Dong-Sheng
He, Min
Jin, Hong-Wei
Tang, Yong-Mei
Zhang, Lian-Hui
Song, Gao-Peng
Cui, Zi-Ning
A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains
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