Bioorganic and Medicinal Chemistry Letters p. 2787 - 2792 (1998)
Update date:2022-08-04
Topics:
Wang, Alan X.
Xie, Qinghua
Lane, Ben
Mollison, Karl W.
Hsieh, Gin C.
Marsh, Kennan
Sheets, Michael P.
Luly, Jay R.
Coghlan, Michael J.
A series of novel pyrazole carboxamides sis disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 < 1 μM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.
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