Synthesis and immunosuppressant activity of pyrazole carboxamides

DOI: 10.1016/S0960-894X(98)00501-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2787 - 2792 (1998)

Update date:2022-08-04

Topics:

Authors:

Wang, Alan X.

Xie, Qinghua

Lane, Ben

Mollison, Karl W.

Hsieh, Gin C.

Marsh, Kennan

Sheets, Michael P.

Luly, Jay R.

Coghlan, Michael J.

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Article abstract of DOI:10.1016/S0960-894X(98)00501-0

A series of novel pyrazole carboxamides sis disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC₅₀ < 1 μM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.

Full text of DOI:10.1016/S0960-894X(98)00501-0

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