Journal of the Chemical Society. Perkin transactions II p. 2031 - 2034 (1986)
Update date:2022-07-30
Topics:
Bowden, Keith
Chehel-Amiran, Mohsen
The detailed mechanism of the methoxide-catalysed rearrangement of substituted benzylidenephthalides and both normal and pseudo methyl o-phenylacetylbenzoates to form 2-phenylindane-1,3-diones has been studied.A rate-acidity function correlation for the reactions in methanolic dimethyl sulphoxide (DMSO) shows a linear increase in rate with increasing H- to reach a maximum in rate before decreasing, except for the p-nitro substrate.This derivative shows a rate decrease throughout the H- range.The ρ values in methanol and in 94 mol percent methanolic DMSO are 1.7 and -1.6, respectively.The kinetic isotope effect has been observed with kH/kD 0.8-1.0.The equilibrium constants for ring-chain tautomerism of the methyl o-phenylacetylbenzoates have been determined and shown to be independent of substituent and solvent composition.The rate-determining step is the intramolecular attack of the anion of the normal ester on the ester carbonyl group.In methanol and methanolic DMSO of high methanol content this is preceded by the ionization equilibrium of the normal ester.In methanolic DMSO of low methanol content and for the p-nitro substrate, the initial state is the anion itself.
View MoreLaohekou Jinghong Chemical Co.,Ltd
Contact:+86-0710-3702747
Address:163.East，Huagong Road，Laohekou
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Contact:13120882795；+86-21-34621078;+86-021-31122318
Address:Suite 2,No.2715 Longwu Road
Contact:+86-717-6370352
Address:168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China
Shanghai Yudiao Chemistry Technology Co.,Ltd
Contact:0086-18964703211
Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
Doi:10.1021/ol035202p
(2003)Doi:10.1016/S0022-328X(00)98041-0
(1976)Doi:10.1016/S0040-4020(03)01134-7
(2003)Doi:10.1002/hlca.194002301115
(1940)Doi:10.1016/S0040-4020(03)01136-0
(2003)Doi:10.1016/S0960-894X(03)00202-6
(2003)
