Journal of Medicinal Chemistry p. 456 - 458 (1977)
Update date:2022-08-04
Topics:
Aultz
McFadden
Lassman
4,10 Dihydro-10-oxofuro[3,2-c][1]benzoxepin-8-acetic acid and 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetic acid were evaluated in the carrageenan paw edema assay with the thieno analogue being ten times more active than the furano compound and 1.3 times more active than indomethacin. The therapeutic ratio (antiinflammatory activity/gastric irritation liability) of the thieno analogue was 25 times that of indomethacin.
View MoreBinzhou Holly Pharmaceutical Co.,Ltd.
Contact:74517
Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
RongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address: Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Tianjin Derchemist Sci-Tech Co., Ltd.
website:http://www.derchemist.com
Contact:+86-22-58627059
Address:Xinmao Science and Technology Park,Huayuan Industrial Park
Changzhou Ansciep Chemical Co.,Ltd.
Contact:+86 519 8630 5871
Address:A-710 Boan International, 8 East Guangdian Road,Wujin,Changzhou
Doi:10.1016/j.bmcl.2005.06.076
(2005)Doi:10.1021/acs.orglett.9b01840
(2019)Doi:10.1002/hlca.19820650702
(1982)Doi:10.1016/S0040-4039(00)85720-2
(1982)Doi:10.1016/j.tetlet.2005.03.020
(2005)Doi:10.1007/BF00808940
(1982)