Journal of Medicinal Chemistry p. 6603 - 6608 (2004)
Update date:2022-08-04
Topics:
Gopalsamy, Ariamala
Lim, Kitae
Ciszewski, Gregory
Park, Kaapjoo
Ellingboe, John W.
Bloom, Jonathan
Insaf, Shabana
Upeslacis, Janis
Mansour, Tarek S.
Krishnamurthy, Girija
Damarla, Murthy
Pyatski, Yelena
Ho, Douglas
Howe, Anita Y. M.
Orlowski, Mark
Feld, Boris
O'Connell, John
A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano-[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.
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