Synthesis of tricycles based on 1,6-anhydro-β-D-hexopyranoses fused with morpholine. 3,10,12-Trioxa-6-azatricyclo[7.2.1.02,7]dodecanes

Article abstract of DOI:10.1135/cccc20031295

The key step of the synthetic route was opening of the oxirane ring in 1,6:3,4-dianhydro-2-O-tosyl-β-D-galactopyranose (1) with 2-chloroethanol to give 1,6-anhydro4-O-(2-chloroethyl)-2-O-tosyl-β-D-glucopyranose (2), which was converted in four steps into