TOTAL SYNTHESIS OF MAYTANSINOIDS. APPROACH TO 4,6-BISDEMETHYLMAYTANSINE AND 4-DEMETHYLMAYTANSINE

Article abstract of DOI:10.1016/S0040-4020(01)88513-6

A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4.In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4,6-bisdemethylmaytansine and 6-demethylmaytansine.The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.