Tetrahedron p. 1895 - 1910 (1992)
Update date:2022-08-04
Topics:
Benechie, Michel
Delpech, Bernard
Khuong-Huu, Qui
Khuong-Huu, Francoise
A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4.In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4,6-bisdemethylmaytansine and 6-demethylmaytansine.The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.
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