Synthesis and Site-Specific Incorporation of a Bay-Region Cis Ring-Opened Tetrahydro Epoxide-Deoxyadenosine Adduct into a DNA Oligomer

Article abstract of DOI:10.1021/jo00038a037

Chemical synthesis of the 1,2,3,4-tetrahydrophenanthrene 3,4-epoxide adducts resulting from benzylic, cis ring-opening of the epoxide by the exocyclic amino group of 2'-deoxyadenosine (dA) is described.The approach taken consists of coupling (+/-)-cis-3-h