Bioorganic and Medicinal Chemistry p. 5738 - 5746 (2014)
Update date:2022-08-04
Topics:
Li, Xiangqian
Liang, Xiaomeng
Song, Ting
Su, Pengchen
Zhang, Zhichao
We report herein characteristic studies of Mcl-1 and Bcl-2 dual inhibitors. It was found that a protruding carbonyl group forming hydrogen bond with R263 plays a predominant role compared with the hydrophobic group that occupies the p2 pocket. A series of dual inhibitors representing different parts of the morpholino-1H-phenalene were designed, synthesized and evaluated.
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Doi:10.1016/j.bmc.2011.08.019
(2011)Doi:10.1021/acs.jmedchem.8b01136
(2018)Doi:10.1021/jm50019a012
(1961)Doi:10.1016/j.tetlet.2003.10.007
(2003)Doi:10.1016/0040-4039(94)88075-1
(1994)Doi:10.1021/jo00399a050
(1978)
