Journal of Medicinal Chemistry p. 1504 - 1508 (1977)
Update date:2022-08-04
Topics:
Filer
Granchelli
Soloway
Neumeyer
A series of 3-amino-4-(p-aminophenyl)isoquinolines bearing the bis (2-chloroethyl)amino group was synthesized as potential CNS antitumor agents. Diol precursors 1e and if were prepared by the treatment of 1b and 1e with ethylene oxide. Diol precursors 5a-c and 9 were prepared by the treatment of 4a-c and 8 with diethanolamine. The reaction of these diols with SOCl2 yielded target mustards 10-15 which were evaluated in the intraperitoneal murine L1210 tumor. No intermediates or target mustards were active in this tumor system.
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Doi:10.1016/S0040-4039(01)93041-2
(1977)Doi:10.1002/mrc.1260271102
(1989)Doi:10.1080/15533174.2012.682691
(2013)Doi:10.1055/s-2003-40820
(2003)Doi:10.1021/jm00215a014
(1977)Doi:10.1021/jm00206a012
(1978)
