Pyridone-containing farnesyltransferase inhibitors: Synthesis and biological evaluation

Article abstract of DOI:10.1016/j.bmcl.2003.08.058

Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed.