Preparation of potential inhibitors of the mur-pathway enzymes on solid support using an acetal linker

Article abstract of DOI:10.1016/S0960-894X(03)00043-X

Here, we report a novel strategy for the combinatorial or parallel solid-phase synthesis of potential inhibitors of the mur-pathway enzymes. The strategy involves the efficient use of p-alkoxybenzylidene acetal linker for reversible immobilization of sugar scaffolds to solid phase. This methodology was used to synthesize several glycopeptides on solid phase in good yields.