Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors

DOI: 10.1021/acs.jmedchem.8b00700

Source and publish data:

Journal of Medicinal Chemistry p. 7741 - 7753 (2018)

Update date:2022-08-15

Topics:

Authors:

Fu, Haigen

Zhang, Jielin

Tepper, Pieter G.

Bunch, Lennart

Jensen, Anders A.

Poelarends, Gerrit J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/acs.jmedchem.8b00700

Aspartate (Asp) derivatives are privileged compounds for investigating the roles governed by excitatory amino acid transporters (EAATs) in glutamatergic neurotransmission. Here, we report the synthesis of various Asp derivatives with (cyclo)alkyloxy and (

Full text of DOI:10.1021/acs.jmedchem.8b00700

Products guided by the article

Product name:D,L-threo-β-Hydroxyasparaginsaeure-dimethylester

Cas No:66620-04-0

R&D Labs maybe for 66620-04-0

Rizhao Lanxing Chemical Indusrial Co.,Ltd

Contact:86-633-2616708

Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
Jining Shengrun Chemical Industry Co., Ltd.

Contact:+86-537-7121666 ,

Address:West Ring Road,Wenshang County Shandong Province
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.

Contact:+86-512-6585 6968

Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Suzhou Tianma Specialty Chemicals Co.,Ltd

Contact:+86-512-68090577

Address:#199, Huayuan Rd, Mudu, Suzhou, Jiangsu, CHINA
Xinjiang Fufeng Biotechnologies Co., Ltd.

Contact:+86-539-7287111

Address:GANQUANPU INDUSTRIAL PARK, ECONOMIC AND TECHNOLOGICAL DEVELOPMENT AREA (TOUTUNHE DISTRICT) OF URUMQI

Relevant to this article

A novel palladium(0)-catalyzed addition of diphenyl disulfide to allenes leading to vicinal disulfides and its application to carbonylation with carbon monoxide

Doi:10.1016/j.tetlet.2007.07.019
(2007)
Synthesis and properties of 1,3-dimethyl-6-azalumazines (isofervenulins)

Doi:10.1248/cpb.26.367
(1978)
Elucidation of the regio- and chemoselectivity of enzymatic allylic oxidations with Pleurotus sapidus - Conversion of selected spirocyclic terpenoids and computational analysis

Doi:10.3762/bjoc.9.262
(2013)
General enantioselective synthesis of butyrolactone natural products via ruthenium-SYNPHOS-catalyzed hydrogenation reactions

Doi:10.1002/adsc.200600504
(2007)
Straightforward Access to 2-Iodoindolizines via Iodine-Mediated Cyclization of 2-Pyridylallenes

Doi:10.1021/acs.oprd.9b00418
(2020)
Doi:10.1021/jo00415a028
(1978)

Article Doi