Bioorganic and Medicinal Chemistry p. 7789 - 7794 (2007)
Update date:2022-07-29
Topics:
Taveira, Aline F.
Hyaric, Mireille Le
Reis, Elaine F.C.
Araujo, Debora P.
Ferreira, Ana Paula
de Souza, Maria Aparecida
Alves, Livia L.
Lourenco, Maria C.S.
Vicente, Felipe Rodrigues C.
de Almeida, Mauro V.
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5 μg/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
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