Synthesis and antimicrobial evaluation of new 1-{[4-(4-Halogenophenyl)-4H- 1,2,4- triazol-3-yl]sulfanyl}acetyl-4-substituted thiosemicarbazides and products of their cyclization

Article abstract of DOI:10.1002/hc.20758

By the reaction of hydrazides of 4-(4-halogenophenyl)-4H-1,2,4-triazol-3- yl-sulfanyl acetic acid with isothiocyanate, 1-acyl-4-substituted thiosemicarbazide derivatives (7-19) were obtained. The cyclization of compounds (7-19) in the presence of 2% NaOH led to the formation of compounds (20-26) containing two 1,2,4-triazole rings connected by a methylenesulfanyl group. The new compounds were tested for their in vitro antimicrobial activity. Some of the tested compounds (9, 12, 18, 21, 22) showed activity against the reference strains of Gram-positive bacteria with the MIC (minimal inhibitory concentration) = 125 to >1000 μg/mL.