
Chemistry of Heterocyclic Compounds p. 727 - 729 (1980)
Update date:2022-07-29
Topics:
Kadzyauskas, P. P.
Malinauskene, Yu. A.
Butkus, E. P.
Zefirov, N. S.
The reductive amination of bicyclo<3.3.1>nonane-2,6-dione with benzylamine or isopropylamine in the presence of sodium borohydride proceeds with the formation of 1-hydroxy-2-(N-substituted)azatwistanes.When 1-hydroxy-2-benzyl-2-azatwistane is refluxed with acetic anhydride, the ring is opened to give 2-acetoxy-6-acetylbenzylaminobicyclo<3.3.1>nonane.The structures of the synthesized compounds were proved by means of the IR and PMR spectra and the results of elementary analysis.
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