Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors

DOI: 10.1016/j.bmcl.2007.07.092

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5595 - 5599 (2007)

Update date:2022-08-05

Topics:

Authors:

Wai, John S.

Kim, Boyoung

Fisher, Thorsten E.

Zhuang, Linghang

Embrey, Mark W.

Williams, Peter D.

Staas, Donnette D.

Culberson, Chris

Lyle, Terry A.

Vacca, Joseph P.

Hazuda, Daria J.

Felock, Peter J.

Schleif, William A.

Gabryelski, Lori J.

Jin, Lixia

Chen, I-Wu

Ellis, Joan D.

Mallai, Rama

Young, Steven D.

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Article abstract of DOI:10.1016/j.bmcl.2007.07.092

A series of potent novel dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 6 is active against replication of HIV

Full text of DOI:10.1016/j.bmcl.2007.07.092

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