SILICON IN SYTHESIS-17 CHLROMETHYL(TRIMETHYLSILYL)LITHIUM-A NEW REAGENT FOR THE DIRECT CONVERSION OF ALDEHYDES AND KETONES INTO α,β-EPOXYTRIMETHYLSILANES

DOI: 10.1016/S0040-4020(01)88585-9

Source and publish data:

Tetrahedron p. 867 - 876 (1983)

Update date:2022-08-04

Topics: Aldehydes Ketones Silicon

Authors:

Burford, Clifford

Cooke, Frank

Roy, Glenn

Magnus, Philip

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Article abstract of DOI:10.1016/S0040-4020(01)88585-9

Treatment of chloromethyltrimethylsilane 1 with sec-BuLi at -78 deg produces chloromethyl(trimethylsilyl)lithium 4.Treatment of 4 with a wide range of aldehydes and ketones gives α,β-epoxytrimethylsilanes 5-28, which on acidic hydrolysis give homologated aldehydes.

Full text of DOI:10.1016/S0040-4020(01)88585-9

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