Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones

Article abstract of DOI:10.1021/jm00373a015

A series of novel triazol-3-ones has been synthesized, and their in vitro and in vivo antifungal properties are reported. Traconazole. which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.