Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel

DOI: 10.1021/jm00119a025

Source and publish data:

Journal of Medicinal Chemistry p. 2218 - 2221 (1988)

Update date:2022-08-03

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Authors:

Brouillette

Brown Brown

DeLorey DeLorey

Shirali Shirali

Grunewald

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Article abstract of DOI:10.1021/jm00119a025

8,9-Dioxo-6-phenyl-1-aza-7-oxabicyclo[4.2.1]nonane (1) and 9,10-dioxo-7-phenyl-1-aza-8-oxabicyclo[5.2.1]decane (2), examples of anti-Bredt bicyclic 2,4-oxalidinediones, were investigated as anticonvulsants in mice. Compound 2 was the more potent (anti-MES

Full text of DOI:10.1021/jm00119a025

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