Bioorganic and Medicinal Chemistry Letters p. 3721 - 3725 (2004)
Update date:2022-08-04
Topics:
Marsilje, Thomas H.
Roses, Jonathan B.
Calderwood, Emily F.
Stroud, Stephen G.
Forsyth, Nancy E.
Blackburn, Christopher
Yowe, David L.
Miao, Wenyan
Drabic, Stacey V.
Bohane, Marie D.
Daniels, J. Scott
Li, Ping
Wu, Lijun
Patane, Michael A.
Claiborne, Christopher F.
A novel series of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R) is reported. Members of this series have been identified, which exhibit sub-micromolar binding affinity for the MC4-R, functional potency <100nM, and good oral exposure in rat. Antagonists of the MC4-R are potentially useful in the therapeutic treatment of involuntary weight loss due to advanced age or disease (e.g. cancer or AIDS), an area of large, unmet medical need.
View MoreShanghai SMEC Trading Co., Ltd.
website:http://www.shanghaismec.com
Contact:+86-21-68811293
Address:ROOM 1101,NO.800 SHANGCHENG RD,SHANGHAI,CHINA
website:http://www.win-winchemical.com
Contact:0086-577-64498589
Address:6F, No. 396 Xingping Road, Longwan Industrial Zone, Wenzhou City, Zhejiang, 325000 P.R.China
LianYunGang Chiral Chemical(CHINA) CO.,LTD
Contact:+86-518-83616958 +86-519-82884848
Address:LianYunGang Chemical Industry Park (JiangSu)
Shandong Yuanli Science and Technology Co., Ltd.
Contact:86-0536-6777557
Address:Zhuliu Industiral Park,Changle County
Feiyang Biotechnology Co., Ltd.
Contact:+86-533-7866339
Address:Qilu Chemistry Park, 200m north of Management Community Building of Park
Doi:10.1021/jm00188a005
(1979)Doi:10.1021/jo01320a019
(1979)Doi:10.1016/j.bmc.2003.12.032
(2004)Doi:10.1021/ic035066k
(2004)Doi:10.1021/jm034243o
(2004)Doi:10.1023/A:1023494629499
(2003)