Tetrahedron p. 6813 - 6817 (2003)
Update date:2022-08-02
Topics:
Reber, Stefan
Kn?pfel, Thomas F.
Carreira, Erick M.
We describe an expeditious enantioselective total synthesis of the acetylenic marine natural products (R)-strongylodiols A and B. Central to the strategy is the use of Zn(OTf)2, amine base, and N-methyl ephedrine to mediate the direct addition of a 1,3-diyne to two long-chain aliphatic aldehydes in useful selectivities and yields.
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Doi:10.1016/j.tetlet.2004.01.123
(2004)Doi:10.1039/DT9780001139
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(2006)Doi:10.1021/ja061165w
(2006)Doi:10.1007/BF00954198
(1982)Doi:10.1016/j.bmc.2006.01.064
(2006)
