Efficient asymmetric hydrogenation of α-amino ketone derivatives. A highly enantioselective synthesis of phenylephrine, levamisole, carnitine and propranolol

DOI: 10.1248/cpb.43.738

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 738 - 747 (1995)

Update date:2022-08-05

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Authors:

Sukuraba

Takahashi

Takeda Takeda

Achiwa Achiwa

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Article abstract of DOI:10.1248/cpb.43.738

The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I) were found to be efficient catalysts for asymmetric hydrogenation of α-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active β-amino alcohols, phenylephrine, levamisole, carnitine and propranolol.

Full text of DOI:10.1248/cpb.43.738

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