Chemical and Pharmaceutical Bulletin p. 738 - 747 (1995)
Update date:2022-08-05
Topics:
Sukuraba
Takahashi
Takeda
Achiwa
The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I) were found to be efficient catalysts for asymmetric hydrogenation of α-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active β-amino alcohols, phenylephrine, levamisole, carnitine and propranolol.
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Doi:10.1021/jo00299a014
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(1950)
