Efficient asymmetric hydrogenation of α-amino ketone derivatives. A highly enantioselective synthesis of phenylephrine, levamisole, carnitine and propranolol

DOI: 10.1248/cpb.43.738

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 738 - 747 (1995)

Update date:2022-08-05

Topics:

Authors:

Sukuraba

Takahashi

Takeda Takeda

Achiwa Achiwa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.738

The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I) were found to be efficient catalysts for asymmetric hydrogenation of α-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active β-amino alcohols, phenylephrine, levamisole, carnitine and propranolol.

Full text of DOI:10.1248/cpb.43.738

NII-Electronic Library Service

Products guided by the article

Product name:(+)-Metoprolol hydrochloride

Cas No:68985-04-6

R&D Labs maybe for 68985-04-6

Shijiazhuang Frontierchem Co., Ltd.

Contact:+86-311-89271196

Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Rugao Jinling Chemical Co., Ltd.(expird)

Contact:0086-513-68005586

Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
Beijing Wisdom Chemicals Co., Ltd.

Contact:+86-10-52350335

Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Hongyi Import & Export CO.,LTD

Contact:86-13319649499

Address:Nanzheng Neighborhood Commitees, Chongwen Office, Yongding District
shanghai Tauto Biotech Co., Ltd

website:http://www.tautobiotech.com/en/index.htm

Contact:+86-21-51320588 ext. 8025

Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA

Relevant to this article

Tetrazolo<1,5-a>pyridines and Furazano<4,5-b>pyridine 1-Oxides

Doi:10.1021/jo00299a014
(1990)
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a]pyridin-6-yl)amino]-9-(tetrahydro-2 H-pyran-4-yl)-7,9-dihydro-8 H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Doi:10.1021/acs.jmedchem.9b01684
(2020)
Broad assessment of bioactivity of a collection of spiroindane pyrrolidines through “cell painting”

Doi:10.1016/j.bmc.2020.115547
(2020)
Potential antitumor agents via inhibitors of L-asparagine synthetase: substituted sulfonamides and sulfonyl hydrazides related to glutamine

Doi:10.1002/jps.2600671115
(1978)
Doi:10.1021/jm00189a018
(1979)
Doi:10.1021/ja01163a058
(1950)

Article Doi