Some reactions of α-hydroxymethylene- and α-dimethylaminomethylene-2,3-polymethylene-3,4-dihydroquinazolin-4-ones

Article abstract of DOI:10.1007/BF00567147

By the reaction of α-hydroxymethylene- and α-dimethylaminomethylene-2,3-polymethylene-3,4-dihydroquinazolin-4-ones with acid anhydrides and primary and secondary amines, the corresponding α-acyloxymethylene- and α-mono(di)-substituted aminomethylene-2,3-polymethylene-3,4-dihydroquinazolin-4-ones have been synthesized. The addition of hydrocyanic acid (from acetone cyanohydrin) to the double bond of the methylene group of the α-hydroxymethylene- and α-dimethylaminomethylene-2,3-trimethylene-3,4-dihydroquinazolin-4-ones has led to α-[cyano-(hydroxy)methyl1]- and α-[cyano(dimethylamino)methyl]-2,3-trimethylene-3,4-dihydroquinazolin-4-ones.