Synthesis of N-substituted cyclic triglycines and their response to metal ions

Article abstract of DOI:10.1016/j.tetlet.2003.10.214

N,N′,N″-Trisubstituted-cyclo-triglycines were synthesized. The major conformation of these compounds has C₃ symmetry, and the carbonyl groups and substituents on the nitrogen are inclined in the same direction. Their response to various metal ions was estimated by constructing ion-selective electrodes. Two of them responded selectively to Ca²⁺ over other cations, demonstrating that N,N′,N″-trisubstituted-cyclo- triglycines provide a new scaffold to act as host molecules.