SYNTHESIS OF 3,9-DIALKYLGUANINES AND THEIR CONVERSION INTO 3-ALKYLWYES, MODELS FOR THE FLUORESCENT NUCLEOSIDES FROM PHENYLALANINE TRANSFER RIBONUCLEIC ACIDS

Article abstract of DOI:10.1016/0040-4020(82)80248-2

Synthesis of 3,9-dialkylguanines 5 has been accomplished by N-cyanation of 1-alkyl-5-(alkylamino)imidazole-4-carboxamides 3 followed by base-catalysed cyclisation.Cyclocondensation of 9-alkyl-3-methylguanines 5a, d, f with MeCOCH₂Br gave 3-alkylwyes 6, model compounds of the most probable structure for wyosine from Torulopsis utilis tRNA^Phe.