The synthesis of (S)-( + )-pantolactone and its analogues from an ephedrine-derived morpholinone

Article abstract of DOI:10.1016/j.tetasy.2004.02.022

An efficient general route for the enantioselective synthesis of (S)-(+)-pantolactone and its analogues has been developed from an ephedrine-derived chiral morpholin-3-one. Selective dialkylation of an ephedrine-derived chiral template without epimerization is the key step in this synthesis.