
Synthesis p. 2007 - 2013 (2019)
Update date:2022-09-26
Topics:
Arita, Mao
Yokoyama, Soichi
Asahara, Haruyasu
Nishiwaki, Nagatoshi
The FeCl 3 -mediated condensation of an α-phenylenamino ester and an enone proceeds efficiently to afford a 2-phenylnicotinate. The subsequent intramolecular Friedel-Crafts reaction yielded an onychine framework. Modifications at the 2-, 3-, and 8-positions of the onychine framework were easily achieved by altering the enamino esters and enones, which facilitated the discovery of potentially bioactive compounds.
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