69751-55-9

Upstream product

• 112583-77-4 2,4-dibenzoyl-3-methylbutene 
• 112539-47-6 2-(3-oxo-1-methyl-3-phenylpropyl)-1-indanone 
• 100-58-3 phenylmagnesium bromide 
• 1346263-77-1 ethyl 4-methyl-2,6-diphenylpyridine-3-carboxylate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 495-41-0 1-phenylbut-2-en-1-one 
• 33831-72-0 ethyl 3-amino-3-phenylprop-2-enoate 
• 1226-91-1 3-methyl-1,5-diphenyl-pentane-1,5-dione 
• 112583-80-9 1-Methyl-3-phenyl-4-azafluorene 
• 112583-78-5 1-dimethylamino-2,4-dibenzoyl-3-methylbutane 

Relevant academic research and scientific papers

Facile Synthesis of Onychines

The FeCl 3 -mediated condensation of an α-phenylenamino ester and an enone proceeds efficiently to afford a 2-phenylnicotinate. The subsequent intramolecular Friedel-Crafts reaction yielded an onychine framework. Modifications at the 2-, 3-, and 8-positions of the onychine framework were easily achieved by altering the enamino esters and enones, which facilitated the discovery of potentially bioactive compounds.

REACTIONS OF 1,5-DIKETONES. XLIX. SYNTHESIS OF THE PHENYL ANALOG OF THE ALKALOID ONYCHINE

1-Methyl-3-phenyl-4-azafluorene was obtained by intramolecular cyclization of 2,4-dibenzoyl-3-methylbutene by the action of sulfuric acid followed by closure of the pyridine ring in the obtained 2-(3-oxo-1-methyl-3-phenylpropyl)-1-indanone by the action o