Communication
Organic & Biomolecular Chemistry
presented here should be of interest for both medicinal and
materials science.
S. Lai, S. Lopez and V. Snieckus, J. Org. Chem., 2007, 72,
1588–1594.
Extended synthetic studies as well as evaluation of the bio-
logical properties of the new azafluorenones synthesized are in
progress. Preliminary tests performed on the functionalized
azafluorenone 17 showed a high antifungal activity against
Candida albicans (higher than nystin) and a high antibacterial
activity against Staphylococcus aureus (higher than
ciprofloxacin).
F. M. gratefully acknowledges the Institut Universitaire
de France and Rennes Métropole for financial support. N. M.,
F. C. and F. M. thank Thermo Fisher for generous gift of
2,2,6,6-tetramethylpiperidine. All the authors thank Thierry
Roisnel (Centre de DIFfractométrie X, UMR 6226) for fruitful
discussion.
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