Journal of Medicinal Chemistry p. 800 - 805 (2006)
Update date:2022-07-30
Topics:
Marson, Charles M.
Savy, Pascal
Rioja, Alphonse S.
Mahadevan, Thevaki
Mikol, Catherine
Veerupillai, Arthi
Nsubuga, Eva
Chahwan, Angela
Joel, Simon P.
The synthesis of a novel series of potent inhibitors of histone deacetylases is described, based on arylsulfinyl-2,4-hexadienoic acid hydroxyamicles and their derivatives. In vitro IC50 values clown to 40 nM were obtained, and several compounds showed inhibition of CEM (human leukemic) cell viability with IC50 of ～1.5 μM, comparable to or better than that of suberoylatiilide hydroxamic acid, an inhibitor of histone cleacetylase currently in clinical trials.
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Doi:10.1002/ejoc.201403655
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