Copper(II)-Catalyzed Alkoxyhalogenation of Alkynyl Ureas and Amides as a Route to Haloalkylidene-Substituted Heterocycles

DOI: 10.1021/acs.joc.5b01227

Source and publish data:

Journal of Organic Chemistry p. 7226 - 7234 (2015)

Update date:2022-08-05

Topics:

Authors:

Gazzola, Silvia

Beccalli, Egle M.

Borelli, Tea

Castellano, Carlo

Chiacchio, Maria Assunta

Diamante, Daria

Broggini, Gianluigi

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Article abstract of DOI:10.1021/acs.joc.5b01227

A highly effective synthesis of haloalkylidene-substituted heterocycles by copper(II)-catalyzed cyclization of alkynyl ureas and secondary amides has been developed. The reaction, which involves a catalytic amount of CuCl₂ and a stoichiometric

Full text of DOI:10.1021/acs.joc.5b01227

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