Copper-catalyzed oxidative C[sbnd]H bond functionalization of N-allylbenzamide for C[sbnd]N and C[sbnd]C bond formation

Article abstract of DOI:10.1016/j.tetlet.2019.04.041

C[sbnd]H bond functionalization for C[sbnd]N and C[sbnd]C bond formations via cross-dehydrogenative coupling (CDC)of N-allylbenzamides with indole as amine source has been developed under a copper-catalyzed condition. To the best of our knowledge, these are the first examples in which different classes of N-containing compounds were directly prepared from the readily available N-allylbenzamides using an inexpensive catalyst-oxidant (CuSO₄/TBHP)system. Further, it was applied for the synthesis of α-substituted N-allylbenzamides by using Grignard reagent as nucleophiles.