Nickel- and Palladium-Catalyzed Cross-Coupling of Aryl Fluorosulfonates and Phosphites: Synthesis of Aryl Phosphonates

Article abstract of DOI:10.1002/ejoc.202001485

The synthesis of aryl phosphonates via nickel and palladium-catalyzed cross-coupling of aryl fluorosulfonates and phosphites is described. The products were obtained in good to excellent yields under mild conditions with broad functional group compatibility, employing either Pd(OAc)₂ and DPEPhos or the readily available NiCl₂(dme) and Xantphos as catalytic systems. Noteworthily, the present C(sp²)?P bond formation method could be applied to the direct conversion of phenols to the corresponding aryl phosphonates in one pot via reaction of phenols with SO₂F₂ and subsequent palladium-catalyzed cross-coupling.