Solvent Effects on Hydrogen-Bond Formation. 2

Article abstract of DOI:10.1021/j100256a015

Thermodynamic parameters for the formation of hydrogen-bonded complexes of phenol and pyrrole with various bases in the solvent cyclohexane, CCl4, and benzene were determined by calorimetric and spectroscopic analysis.These parameters are strongly influenced by solvent.The enthalpy changes and equilibrium constants for the phenol-DMA complex in cyclohexane and benzene are -9.0 kcal mol^-1 and 433 and -6.3 kcal mol^-1 and 71, respectively.A simple model for solvation effects has been proposed.The model requires that the solute-solvent interactions that occur at those binding sites used in the formation of the complex be overcome before the complex can be formed.These interaction site enthalpies have been determined by calorimetric analysis and used to test the model.