Synthesis and Antibacterial Activities of 4-Pyrrolidinylthio Carbapenems: Containing Heteroaromatics as a Side Chain

Article abstract of DOI:10.1002/ardp.200300728

The synthesis of a new series of 2-alkyl-4-pyrrolidinylthio-b-methylcarbapenems containing the substituted heteroaromatic moieties is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested. The effect of substituents on the nitrogen atoms at heteroaromatic rings was investigated. Particular compounds (14b, 14c) containing 3-methyl- and 3,5-dimethylpyrazolethio substituted moiety showed the most potent antibacterial activity.